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Breast cancer in young women: the effect of age on tumor biology and prognosis

In Clinical Cancer Investigation Journal
By: Sivakumar P.
Contributor(s): Ravi C | | Rodrigues G.
Material type: materialTypeLabelArticleSeries: Vol 4 Issues 2.Publisher: 2015Description: 165-169.Subject(s): recurrence | mortality | metastasis | Breast cancer | DDC classification: In: Clinical Cancer Investigation JournalSummary: Background: Breast cancer (BC) is primarily a disease of older or postmenopausal women. Due to the small number of reported patients and difficulty in diagnosing BC in younger women studying this disease in this group has been challenging. Controversy exists regarding the relationship between age and prognosis as young women have generally been found to have a poor prognosis. This study compares breast carcinoma in women above and below 35 years of age highlighting age as an adverse factor in the presentation, recurrence, and prognosis of the disease. Materials and Methods: Two hundred and seventy-nine patients, having undergone a BC operation at a tertiary-care center between June 2005 and June 2010 were studied. Prognosis of breast carcinoma in women above and below 35 years was compared based on the stage and grade of the disease at the time of presentation, estrogen receptor/progesterone receptor (ER/PR) and HER2/neu status, recurrent disease on follow-up and mortality. Comparisons between these factors
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Background: Breast cancer (BC) is primarily a disease of older or postmenopausal women. Due to the small number of reported patients and difficulty in diagnosing BC in younger women studying this disease in this group has been challenging. Controversy exists regarding the relationship between age and prognosis as young women have generally been found to have a poor prognosis. This study compares breast carcinoma in women above and below 35 years of age highlighting age as an adverse factor in the presentation, recurrence, and prognosis of the disease. Materials and Methods: Two hundred and seventy-nine patients, having undergone a BC operation at a tertiary-care center between June 2005 and June 2010 were studied. Prognosis of breast carcinoma in women above and below 35 years was compared based on the stage and grade of the disease at the time of presentation, estrogen receptor/progesterone receptor (ER/PR) and HER2/neu status, recurrent disease on follow-up and mortality. Comparisons between these factors

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